Background Parasitic diseases are one of the world's most devastating and prevalent
infections, causing millions of morbidities and mortalities annually. In the past, many of these …

With increasing concerns about public health and the development of molecular techniques,
new detection tools and the combination of existing approaches have increased the abilities …

A highly protective malaria vaccine would greatly facilitate the prevention and elimination of
malaria and containment of drug-resistant parasites. A high level (more than 90%) of …

BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ)
malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf …

Background Planning and evaluating malaria control strategies relies on accurate definition
of parasite prevalence in the population. A large proportion of asymptomatic parasite …

We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI)
of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ)(PfSPZ …

Background CRISPR-based diagnostics are a new class of highly sensitive and specific
assays with multiple applications in infectious disease diagnosis. SHERLOCK, or Specific …

Background A very large biomass of intact asexual-stage malaria parasites accumulates in
the spleen of asymptomatic human individuals infected with Plasmodium vivax. The …

Accurate quantification of parasite density in the human host is essential for understanding
the biology and pathology of malaria. Semi-quantitative molecular methods are widely …

Background RH5 is a leading blood-stage candidate antigen for a Plasmodium falciparum
vaccine; however, its safety and immunogenicity in malaria-endemic populations are …