Abstract Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-
inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …

An intact intestinal barrier, representing the interface between inner and outer environments,
is an integral regulator of health. Among several factors, bacteria and their products have …

Intracellular surveillance for systemic microbial components during homeostasis and
infections governs host physiology and immunity. However, a long-standing question is how …

Sepsis, the most common cause of admission to an intensive care unit (ICU), has had an
increased incidence and prevalence over the last years with a simultaneous decrease in its …

Diabetes Mellitus (DM) is an inflammatory clinical entity with different mechanisms involved
in its physiopathology. Among these, the dysfunction of the gut microbiota stands out …

Clinical trials have unequivocally shown that inhibition of proprotein convertase
subtilisin/kexin type 9 (PCSK9) efficaciously and safely prevents cardiovascular events by …

Physiologically, lipopolysaccharide (LPS) is present in the bloodstream and can be bound to
several proteins for its transport (ie) LPS binding protein (LBP) and plasma lipoproteins) …

Background: Alow carbohydrate diet (LCD) is more beneficial for the glycometabolism in
type 2 diabetes (T2DM) and may be effective in reducing depression. Almond, which is a …

Methods: Wild-type, PCSK9 knockout (KO), and transgenic (Tg) mice that overexpress
PCSK9 were subjected to sham surgery or cecal ligation and puncture (CLP). Bacterial …

PCSK9 (proprotein convertase subtilisin kexin type 9) is a liver secretory enzyme that
regulates plasma low-density lipoprotein (LDL) cholesterol (LDL-C) levels through …