The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis

A Blauvelt, A Chiricozzi - Clinical reviews in allergy & immunology, 2018 - Springer
Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven
by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17 …

Mucosal-associated invariant T cells and disease

A Toubal, I Nel, S Lotersztajn, A Lehuen - Nature Reviews Immunology, 2019 - nature.com
Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate
and adaptive immunity. They are activated by conserved bacterial ligands derived from …

[HTML][HTML] Health consequences of thymus removal in adults

KA Kooshesh, BH Foy, DB Sykes… - … England Journal of …, 2023 - Mass Medical Soc
Background The function of the thymus in human adults is unclear, and routine removal of
the thymus is performed in a variety of surgical procedures. We hypothesized that the adult …

The gut microbiota in IBD

C Manichanh, N Borruel, F Casellas… - Nature reviews …, 2012 - nature.com
IBD—ulcerative colitis and Crohn's disease—is emerging as a worldwide epidemic. An
association between the increased incidence of IBD and environmental factors linked to …

Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases

NE Serriari, M Eoche, L Lamotte, J Lion… - Clinical & …, 2014 - academic.oup.com
Inflammatory bowel diseases are characterized by a deregulated immune response
targeting the gut bacterial flora. Mucosal-associated invariant T (MAIT) cells are major …

Th17 cells in immunity and autoimmunity

SK Bedoya, B Lam, K Lau… - Journal of Immunology …, 2013 - Wiley Online Library
Th17 and IL‐17 play important roles in the clearance of extracellular bacterial and fungal
infections. However, strong evidence also implicates the Th17 lineage in several …

The role of IL-17 and anti-IL-17 agents in the immunopathogenesis and management of autoimmune and inflammatory diseases

SPDG Berry, C Dossou, A Kashif, N Sharifinejad… - International …, 2022 - Elsevier
Abstract Interleukin-17 (IL-17) is a proinflammatory cytokine involved in chronic inflammation
occurring during the pathogenesis of allergy, malignancy, and autoimmune diseases such …

Where does a Staphylococcus aureus vaccine stand?

VG Fowler Jr, RA Proctor - Clinical Microbiology and Infection, 2014 - Wiley Online Library
In this review, we examine the current status of S taphylococcus aureus vaccine
development and the prospects for future vaccines. Examination of the clinical trials to date …

Transcriptional and epigenetic regulation of T‐helper lineage specification

SK Tripathi, R Lahesmaa - Immunological reviews, 2014 - Wiley Online Library
Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …

Immune control by TRAF6-mediated pathways of epithelial cells in the EIME (epithelial immune microenvironment)

T Dainichi, R Matsumoto, A Mostafa… - Frontiers in …, 2019 - frontiersin.org
In the protective responses of epithelial tissues, not only immune cells but also non-immune
cells directly respond to external agents. Epithelial cells can be involved in the organization …