An update on safety and side effects of cannabidiol: a review of clinical data and relevant animal studies

K Iffland, F Grotenhermen - Cannabis and cannabinoid research, 2017 - liebertpub.com
Introduction: This literature survey aims to extend the comprehensive survey performed by
Bergamaschi et al. in 2011 on cannabidiol (CBD) safety and side effects. Apart from …

Role of cannabidiol in the therapeutic intervention for substance use disorders

F Navarrete, MS García-Gutiérrez… - Frontiers in …, 2021 - frontiersin.org
Drug treatments available for the management of substance use disorders (SUD) present
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …

Pharmacokinetic and behavioural profile of THC, CBD, and THC+ CBD combination after pulmonary, oral, and subcutaneous administration in rats and confirmation of …

T Hložek, L Uttl, L Kadeřábek, M Balíková… - European …, 2017 - Elsevier
Metabolic and behavioural effects of, and interactions between Δ9-tetrahydrocannabinol
(THC) and cannabidiol (CBD) are influenced by dose and administration route. Therefore …

Cannabidiol does not display drug abuse potential in mice behavior

A Viudez-Martínez, MS García-Gutiérrez… - Acta Pharmacologica …, 2019 - nature.com
Recent evidence suggests that cannabidiol (CBD) may be useful for the treatment of
different neuropsychiatric disorders. However, some controversy regarding its profile as a …

Behavioral tasks evaluating schizophrenia-like symptoms in animal models: a recent update

MJ Ang, S Lee, JC Kim, SH Kim… - Current …, 2021 - ingentaconnect.com
Background: Schizophrenia is a serious mental illness that affects more than 21 million
people worldwide. Both genetics and the environment play a role in its etiology and …

Is cannabidiol during neurodevelopment a promising therapy for schizophrenia and autism spectrum disorders?

CM Loss, L Teodoro, GD Rodrigues… - Frontiers in …, 2021 - frontiersin.org
Schizophrenia and autism spectrum disorders (ASD) are psychiatric neurodevelopmental
disorders that cause high levels of functional disabilities. Also, the currently available …

Effects of cannabidiol plus naltrexone on motivation and ethanol consumption

A Viudez‐Martínez, MS García‐Gutiérrez… - British journal of …, 2018 - Wiley Online Library
Background and Purpose The aim of this study was to explore if the administration of
naltrexone together with cannabidiol (CBD) may improve the efficacy in reducing alcohol …

Capsaicin alleviates neuronal apoptosis and schizophrenia-like behavioral abnormalities induced by early life stress

S Xu, K Hao, Y Xiong, R Xu, H Huang, H Wang - Schizophrenia, 2023 - nature.com
Early life stress (ELS) is associated with the later development of schizophrenia. In the
rodent model, the maternal separation (MS) stress may induce neuronal apoptosis and …

Pharmacological and behavioral effects of the synthetic cannabinoid AKB48 in rats

S Bilel, M Tirri, R Arfè, S Stopponi… - Frontiers in …, 2019 - frontiersin.org
AKB48 is a designer drug belonging to the indazole synthetic cannabinoids class, illegally
sold as herbal blend, incense, or research chemicals for their psychoactive cannabis-like …

Investigating Cannabidiol's Potential as a Supplementary Treatment for Schizophrenia: A Narrative Review

JSD Völker, MDPDIV Micluția, RC Vinași - European Journal of …, 2024 - Elsevier
Schizophrenia presents a complex mental health challenge, often inadequately addressed
by existing antipsychotic treatments, leading to persistent symptoms and adverse effects …