Liver fibrosis is an excessive and imbalanced deposition of fibrous extracellular matrix
(ECM) that is associated with the hepatic wound-healing response. It is also the common …

Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz
Disse, the structure and functions of the space of Disse, a thin perisinusoidal area between …

Background & Aims We investigated mechanisms of hepatic stellate cell (HSC) activation,
which contributes to liver fibrogenesis. We aimed to determine whether activated HSCs …

During chronic liver disease, macrophages support angiogenesis, not only by secreting
proangiogenic growth factors and matrix-remodeling proteases, but also by physically …

The cytoplasmic polyadenylation element-binding (CPEB) proteins regulate pre-mRNA
processing and translation of CPE-containing mRNAs in early embryonic development and …

Background & Aims Liver sinusoidal endothelial cells (LSECs) are ideally situated to sense
stiffness and generate angiocrine programs that potentially regulate liver fibrosis and portal …

Chronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the
incidence of liver disease is dramatically rising due to the aging of the population and the …

Molecular and cellular research modalities for the study of liver pathologies have been
tremendously improved over the recent decades. Advanced technologies offer novel …

This review chapter describes the current knowledge about the nature of pericytes in the gut,
their interaction with endothelial cells in blood vessels, and their pathophysiological …

Abstract Development of portosystemic collateral vessels and gastroesophageal varices is
responsible for the most serious clinical consequences of portal hypertension, but effective …