Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality.
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …

Gastric cancer displays marked molecular heterogeneity with aggressive behavior and
treatment resistance. Therefore, good in vitro models that encompass unique subtypes are …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Cell migration is essential for many biological processes, while abnormal cell migration is
characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to …

Abstract N6-methyladenosine (m6A) is the most prevalent internal RNA modification in
mammals that regulates homeostasis and function of modified RNA transcripts. Here, we …

Like most solid tumours, the microenvironment of epithelial-derived gastric adenocarcinoma
(GAC) consists of a variety of stromal cell types, including fibroblasts, and neuronal …

Gastric cancers, with gastric adenocarcinoma (GAC) as the most common histological type,
impose a considerable global health burden. Although the screening strategies for early …

Understanding tumor microenvironment (TME) reprogramming in gastric adenocarcinoma
(GAC) progression may uncover novel therapeutic targets. Here, we performed single-cell …

The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …