[HTML][HTML] Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer

P Nowak-Sliwinska, L Scapozza, AR i Altaba - Biochimica et Biophysica …, 2019 - Elsevier
The strategy of using existing drugs originally developed for one disease to treat other
indications has found success across medical fields. Such drug repurposing promises faster …

Human endogenous retrovirus K (HML-2) in health and disease

B Xue, LA Sechi, DJ Kelvin - Frontiers in microbiology, 2020 - frontiersin.org
Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections
in the evolution of primates and account for about 8% of the human genome. They were …

[HTML][HTML] Human endogenous retroviruses and cancer

M Gonzalez-Cao, P Iduma, N Karachaliou… - Cancer biology & …, 2016 - ncbi.nlm.nih.gov
Human endogenous retroviruses (HERVs) are retroviruses that infected human genome
millions of years ago and have persisted throughout human evolution. About 8% of our …

Association between Human Endogenous Retrovirus K gene expression and breast cancer

M Tourang, L Fang, Y Zhong… - Cellular, Molecular and …, 2021 - cmbr-journal.com
Breast cancer is one of the most common cancers known, and it is also a significant cause of
death in women. If breast cancer is diagnosed in the early stages of the disease and treated …

Downregulation of Human Endogenous Retrovirus Type K (HERV-K) Viral env RNA in Pancreatic Cancer Cells Decreases Cell Proliferation and Tumor Growth

M Li, L Radvanyi, B Yin, K Rycaj, J Li, R Chivukula… - Clinical Cancer …, 2017 - AACR
Purpose: We investigated the role of the human endogenous retrovirus type K (HERV-K)
envelope (env) gene in pancreatic cancer. Experimental Design: shRNA was employed to …

HERVs and cancer—A comprehensive review of the relationship of human endogenous retroviruses and human cancers

E Stricker, EC Peckham-Gregory, ME Scheurer - Biomedicines, 2023 - mdpi.com
Genomic instability and genetic mutations can lead to exhibition of several cancer hallmarks
in affected cells such as sustained proliferative signaling, evasion of growth suppression …

[HTML][HTML] Human endogenous retroviruses in development and disease

J Mao, Q Zhang, YS Cong - Computational and Structural Biotechnology …, 2021 - Elsevier
Human endogenous retroviruses (HERVs) represent∼ 8% of human genome, deriving from
exogenous retroviral infections of germ line cells occurred millions of years ago and being …

Ancient adversary–HERV-K (HML-2) in cancer

E Dervan, DD Bhattacharyya, JD McAuliffe… - Frontiers in …, 2021 - frontiersin.org
Human endogenous retroviruses (HERV), ancient integrations of exogenous viruses, make
up 8% of our genome. Long thought of as mere vestigial genetic elements, evidence is now …

Molecular functions of human endogenous retroviruses in health and disease

M Suntsova, A Garazha, A Ivanova, D Kaminsky… - Cellular and Molecular …, 2015 - Springer
Human endogenous retroviruses (HERVs) and related genetic elements form 504 distinct
families and occupy~ 8% of human genome. Recent success of high-throughput …

Human endogenous retroviruses role in cancer cell stemness

C Matteucci, E Balestrieri, A Argaw-Denboba… - Seminars in cancer …, 2018 - Elsevier
Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the
critical issues of oncological diseases. In this scenario, increasing scientific evidences …