Cas9 is mostly orthogonal to human systems of DNA break sensing and repair

EA Maltseva, IA Vasil'eva, NA Moor, DV Kim… - Plos one, 2023 - journals.plos.org
CRISPR/Cas9 system is а powerful gene editing tool based on the RNA-guided cleavage of
target DNA. The Cas9 activity can be modulated by proteins involved in DNA damage …