Tauopathies, synucleinopathies, Aβ amyloidosis, TDP-43 proteinopathies, and prion
diseases-these neurodegenerative diseases have in common the formation of amyloid …

The functionality of the central nervous system (CNS) relies on the connection, integration,
and the exchange of information among neural cells. The crosstalk among glial cells and …

Ultrastructure of human brain tissue has traditionally been examined using electron
microscopy (EM) following fixation, staining, and sectioning, which limit resolution and …

Communication between neurons and glia significantly influences the development
maturation, plasticity, and disease progressions of the nervous system. As a new signaling …

The pathological deposition of proteins is a hallmark of several devastating
neurodegenerative diseases. These pathological deposits comprise aggregates of proteins …

Synaptic dysfunction is one of the earliest cellular defects observed in Alzheimer's disease
(AD) and Parkinson's disease (PD), occurring before widespread protein aggregation …

Ultrastructure of human brain tissue has traditionally been examined using electron
microscopy (EM) following chemical fixation, staining, and mechanical sectioning, which …

Aging presents progressive changes that increase the susceptibility of the central nervous
system (CNS) to suffer neurological disorders (NDs). Several studies have reported that an …

Alzheimer's disease (AD) is associated with memory and cognitive impairment caused by
progressive degeneration of neurons. The events leading to neuronal death are associated …

Dementia is a general term for conditions impairing cognitive abilities including perception,
reasoning, attention, judgment, memory, and daily brain function. Early diagnosis of …