The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by sustained
hyperglycemia caused by impaired insulin signaling and secretion. Metabolic stress, caused …

Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here,
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …

In vitro differentiation of human induced pluripotent stem cells (iPSCs) into beta cells
represents an important cell source for diabetes research. Here, we fully characterized iPSC …

In a patient with permanent neonatal syndromic diabetes clinically similar to cases with
ONECUT1 biallelic mutations, we identified a disease-causing deletion located upstream of …

Aims/hypothesis TNF-α plays a role in pancreatic beta cell loss in type 1 diabetes mellitus. In
clinical interventions, TNF-α inhibition preserves C-peptide levels in early type 1 diabetes. In …

Recessive mutations in DNAJC3, an endoplasmic reticulum (ER)-resident BiP co-
chaperone, have been identified in patients with multisystemic neurodegeneration and …

Summary LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation
using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse …

Impaired redox homeostasis in the endoplasmic reticulum (ER) may contribute to proinsulin
misfolding and thus to activate the unfolded protein response (UPR) and apoptotic …

Diabetes mellitus (DM), is a chronic disorder characterized by impaired glucose
homeostasis that results from the loss or dysfunction of pancreatic β-cells leading to type 1 …