Beneficial effects and neurobiological aspects of environmental enrichment associated to major depressive disorder and autism spectrum disorder

LM Manosso, LDR Broseghini, JMB Campos… - Brain Research …, 2022 - Elsevier
A suitable enriched environment favors development but can also influence behavior and
neuronal circuits throughout development. Studies have shown that environmental …

Τhe neuroprotective role of environmental enrichment against behavioral, morphological, neuroendocrine and molecular changes following chronic unpredictable …

Ε Dandi, E Spandou, C Dalla… - European Journal of …, 2023 - Wiley Online Library
Environmental factors interact with biological and genetic factors influencing the
development and well‐being of an organism. The interest in better understanding the role of …

Effects of adolescent administration of fluoxetine on novel object recognition memory, anxiety-like behaviors, and hippocampal brain-derived neurotrophic factor level

F Sadegzadeh, N Sakhaie, R Dehghany, O Adak… - Life sciences, 2020 - Elsevier
Aims Fluoxetine (FLX) is a common selective serotonin reuptake inhibitor, which is used in
adolescents with psychiatric disorders. Controversial results have been obtained in different …

Investigating the role of environmental enrichment initiated in adolescence against the detrimental effects of chronic unpredictable stress in adulthood: Sex-specific …

E Dandi, E Spandou, DA Tata - Behavioural Processes, 2022 - Elsevier
Environmental Enrichment (EE) improves cognitive function and enhances brain plasticity,
while chronic stress increases emotionality, impairs learning and memory, and has adverse …

Alterations in the behavior, cognitive function, and BDNF level in adult male rats following neonatal blockade of GABA-A receptors

P Naderipoor, M Amani, A Abedi, N Sakhaie… - Brain Research …, 2021 - Elsevier
Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the mature
brain. At an early developmental period, it acts in an excitatory manner that influences many …

Enriched environment alleviates neurological deficits via downregulation of Cx43 after experimental stroke

X Chen, W Wang, H Li, X Zhang - Brain Research, 2023 - Elsevier
While it has been demonstrated that enriched environment (EE) can protect against cerebral
ischemia/reperfusion (I/R) injury, the underlying mechanism remains largely unknown …

Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats

H Saadati, F Sadegzadeh, N Sakhaie… - International Journal …, 2021 - Wiley Online Library
A survey of the literature indicates that the developmental disruptions in serotonin (5‐HT)
levels can influence the brain development and the function. To the best of our knowledge …

Environmental enrichment as a strategy: Attenuates the anxiety and memory impairment in social isolation stress

S Keloglan Musuroglu, DM Ozturk… - International Journal …, 2022 - Wiley Online Library
Background Social isolation (SI) early in life produces behavioral and cognitive
abnormalities. On the contrary, environmental enrichment (EE) offers beneficial effects on …

Calcitriol supplementation attenuates cisplatin-induced behavioral and cognitive impairments through up-regulation of BDNF in male rats

H Panahpour, S Ghaheri, H Saadati - Brain Research Bulletin, 2022 - Elsevier
Chemotherapy-induced cognitive impairment such as memory impairment and
concentration problems are now extensively recognized as side effects of chemotherapy …

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a …

Ε Dandi, P Theotokis, MC Petri… - Developmental …, 2023 - Wiley Online Library
This study aims at investigating whether environmental enrichment (EE) initiated in
adolescence can alter chronic unpredictable stress (CUS)‐associated changes in astroglial …