Gradients and consequences of heterogeneity in biofilms
Historically, appreciation for the roles of resource gradients in biology has fluctuated
inversely to the popularity of genetic mechanisms. Nevertheless, in microbiology specifically …
inversely to the popularity of genetic mechanisms. Nevertheless, in microbiology specifically …
Chromosome organization in bacteria: mechanistic insights into genome structure and function
Bacterial chromosomes are folded to compact DNA and facilitate cellular processes.
Studying model bacteria has revealed aspects of chromosome folding that are applicable to …
Studying model bacteria has revealed aspects of chromosome folding that are applicable to …
Redefining fundamental concepts of transcription initiation in bacteria
Despite enormous progress in understanding the fundamentals of bacterial gene regulation,
our knowledge remains limited when compared with the number of bacterial genomes and …
our knowledge remains limited when compared with the number of bacterial genomes and …
Bacterial stress responses during host infection
FC Fang, ER Frawley, T Tapscott, A Vázquez-Torres - Cell host & microbe, 2016 - cell.com
Pathogenic bacteria must withstand diverse host environments during infection.
Environmental signals, such as pH, temperature, nutrient limitation, etc., not only trigger …
Environmental signals, such as pH, temperature, nutrient limitation, etc., not only trigger …
Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli
The ferric uptake regulator (Fur) plays a critical role in the transcriptional regulation of iron
metabolism. However, the full regulatory potential of Fur remains undefined. Here we …
metabolism. However, the full regulatory potential of Fur remains undefined. Here we …
High-Level dCas9 Expression Induces Abnormal Cell Morphology in Escherichia coli
Along with functional advances in the use of CRISPR/Cas9 for genome editing,
endonuclease-deficient Cas9 (dCas9) has provided a versatile molecular tool for exploring …
endonuclease-deficient Cas9 (dCas9) has provided a versatile molecular tool for exploring …
Genome-wide reconstruction of OxyR and SoxRS transcriptional regulatory networks under oxidative stress in Escherichia coli K-12 MG1655
Summary Three transcription factors (TFs), OxyR, SoxR, and SoxS, play a critical role in
transcriptional regulation of the defense system for oxidative stress in bacteria. However …
transcriptional regulation of the defense system for oxidative stress in bacteria. However …
Comprehensive Mapping of the Escherichia coli Flagellar Regulatory Network
DM Fitzgerald, RP Bonocora, JT Wade - PLoS genetics, 2014 - journals.plos.org
Flagellar synthesis is a highly regulated process in all motile bacteria. In Escherichia coli
and related species, the transcription factor FlhDC is the master regulator of a multi-tiered …
and related species, the transcription factor FlhDC is the master regulator of a multi-tiered …
Tyrosol blocks E. coli anaerobic biofilm formation via YbfA and FNR to increase antibiotic susceptibility
HY Choi, WG Kim - Nature communications, 2024 - nature.com
Bacteria within mature biofilms are highly resistant to antibiotics than planktonic cells.
Oxygen limitation contributes to antibiotic resistance in mature biofilms. Nitric oxide (NO) …
Oxygen limitation contributes to antibiotic resistance in mature biofilms. Nitric oxide (NO) …
Translating new synthetic biology advances for biosensing into the earth and environmental sciences
The rapid diversification of synthetic biology tools holds promise in making some classically
hard-to-solve environmental problems tractable. Here we review longstanding problems in …
hard-to-solve environmental problems tractable. Here we review longstanding problems in …