DNA end resection: mechanism and control
P Cejka, LS Symington - Annual review of genetics, 2021 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genome integrity and
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
The plasticity of DNA replication forks in response to clinically relevant genotoxic stress
Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …
Two replication fork remodeling pathways generate nuclease substrates for distinct fork protection factors
Fork reversal is a common response to replication stress, but it generates a DNA end that is
susceptible to degradation. Many fork protection factors block degradation, but how they …
susceptible to degradation. Many fork protection factors block degradation, but how they …
Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases
L Zheng, Y Meng, JL Campbell… - Nucleic acids research, 2020 - academic.oup.com
DNA2 nuclease/helicase is a structure-specific nuclease, 5′-to-3′ helicase, and DNA-
dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki …
dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki …
The emerging determinants of replication fork stability
T Thakar, GL Moldovan - Nucleic acids research, 2021 - academic.oup.com
A universal response to replication stress is replication fork reversal, where the nascent
complementary DNA strands are annealed to form a protective four-way junction allowing …
complementary DNA strands are annealed to form a protective four-way junction allowing …
WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
Cellular feedback systems ensure genome maintenance during DNA replication. When
replication forks stall, newly replicated DNA is protected by pathways that limit excessive …
replication forks stall, newly replicated DNA is protected by pathways that limit excessive …
Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress
A de Jaime-Soguero, J Hattemer, A Bufe… - Nature …, 2024 - nature.com
Human development relies on the correct replication, maintenance and segregation of our
genetic blueprints. How these processes are monitored across embryonic lineages, and why …
genetic blueprints. How these processes are monitored across embryonic lineages, and why …
[HTML][HTML] A fork in the road: Where homologous recombination and stalled replication fork protection part ways
S Tye, GE Ronson, JR Morris - Seminars in Cell & Developmental Biology, 2021 - Elsevier
In response to replication hindrances, DNA replication forks frequently stall and are
remodelled into a four-way junction. In such a structure the annealed nascent strand is …
remodelled into a four-way junction. In such a structure the annealed nascent strand is …
H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
R Bayley, V Borel, RJ Moss, E Sweatman, P Ruis… - Molecular Cell, 2022 - cell.com
Summary The 53BP1-RIF1-shieldin pathway maintains genome stability by suppressing
nucleolytic degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 …
nucleolytic degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 …
RNA: DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation
C Audoynaud, K Schirmeisen, AA Saada, A Gesnik… - Molecular Cell, 2023 - cell.com
Nonhomologous end-joining (NHEJ) factors act in replication-fork protection, restart, and
repair. Here, we identified a mechanism related to RNA: DNA hybrids to establish the NHEJ …
repair. Here, we identified a mechanism related to RNA: DNA hybrids to establish the NHEJ …