G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …

Oligomerization of membrane proteins has received intense research interest because of
their importance in cellular signaling and the large pharmacological and clinical potential …

G protein-coupled receptors (GPCRs) are important drug targets that mediate various
signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its …

The technique of cryogenic-electron microscopy (cryo-EM) has revolutionized the field of
membrane protein structure and function with a focus on the dominantly observed molecular …

G protein-coupled receptors (GPCRs) are prominent drug targets responsible for
extracellular-to-intracellular signal transduction. GPCRs can form functional dimers that …

CXCL17 is a chemokine principally expressed by mucosal tissues, where it facilitates
chemotaxis of monocytes, dendritic cells, and macrophages and has antimicrobial …

While the existence and functional role of class C G-protein-coupled receptors (GPCR)
dimers is well established, there is still a lack of consensus regarding class A and B GPCR …

A key question in receptor signaling is how specificity is realized, particularly when different
receptors trigger the same biochemical pathway (s). A notable case is the two β‐adrenergic …

The histamine H3 receptor (H3R) is considered an attractive drug target for various
neurological diseases. We here report the synthesis of UR-NR266, a novel fluorescent H3R …

Blinking occurs with nearly all fluorophores including organic dyes, fluorescent proteins,
semiconductor quantum dots and carbon dots (CDs). We developed non-blinking and …