Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …

While half of the world's population is at risk of malaria, the most vulnerable are still children
under five, pregnant women and returning travelers. Anopheles mosquitoes transmit malaria …

Cerebral malaria (CM) is one of the leading causes of death due to malaria. It is
characterised by coma, presence of asexual parasites in blood smear, and absence of any …

Vector‐borne infectious diseases are still an important global health problem. Malaria is the
most important among them, mainly pediatric, life‐threatening disease. Malaria and other …

Malaria is a frequent parasitic infection becomes life threatening due to the disequilibrated
immune responses of the host. Avid phagocytosis of malarial pigment hemozoin (HZ) and …

Plasmodium parasites contain various virulence factors that modulate the host immune
response. Malarial pigment, or hemozoin (Hz), is an undegradable crystalline product of the …

Dendritic cells (DCs) play a central role in the initiation of adaptive immune responses,
efficiently presenting antigens to T cells. This ability relies on the presence of numerous …

The host response against infection with Plasmodium commonly raises self-reactivity as a
side effect, and antibody deposition in kidney has been cited as a possible cause of kidney …

A better understanding of stable changes in regulation of gene expression that result from
epigenetic events is of great relevance in the development of strategies to prevent and treat …

Malarial pigment hemozoin (HZ) generates the lipoperoxidation product 4-hydroxynonenal
(4-HNE), which is known to cause dysregulation of the immune response in malaria. The …