Pancreatic β-cell function is of critical importance in the regulation of fuel homoeostasis, and
metabolic dysregulation is a hallmark of diabetes mellitus (DM). The β-cell is an intricately …

Insulin-like growth factor 1 (IGF-1) is a key anabolic growth factor stimulating
phosphatidylinositol 3-kinase (PI3K)/Akt signaling which is well known for regulating muscle …

Skeletal muscles, being one of the most abundant tissues in the body, are involved in many
vital processes, such as locomotion, posture maintenance, respiration, glucose …

Background/Aims: The purpose of the study was to assess the amount of rRNA and
phosphorylation status of the key markers of mTORC1-dependent (70s6k, 4E-BP1) and …

Chronic obstructive pulmonary disease (COPD) is characterized by weight loss, muscle
wasting (in advanced disease ultimately resulting in cachexia), and loss of muscle oxidative …

Abstract Aim: Skeletal muscle interleukin‐6 (IL‐6) expression is induced by continuous
contraction, overload‐induced hypertrophy and during muscle regeneration. The loss of IL‐6 …

Skeletal muscle fibers have a unique capacity to adjust their metabolism and phenotype in
response to alternations in mechanical loading. Indeed, chronic mechanical loading leads to …

Background Aberrant skeletal muscle mitochondrial oxidative metabolism is a debilitating
feature of chronic diseases such as chronic obstructive pulmonary disease, type 2 diabetes …

Muscle wasting impairs physical performance, increases mortality and reduces medical
intervention efficacy in chronic diseases and cancer. Developing proficient intervention …

Androgens promote anabolism in the musculoskeletal system while generally repressing
adiposity, leading to lean body composition. Circulating androgens decline with age …