Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine
In cancer, one of the main barriers to effective chemotherapy is inefficient drug delivery. The
delivery of drugs to solid tumors involves various biochemical, biophysical, and mechanical …
delivery of drugs to solid tumors involves various biochemical, biophysical, and mechanical …
The vascular microenvironment in glioblastoma: a comprehensive review
A Mosteiro, L Pedrosa, A Ferrés, D Diao, À Sierra… - Biomedicines, 2022 - mdpi.com
Glioblastoma multiforme, the deadliest primary brain tumor, is characterized by an excessive
and aberrant neovascularization. The initial expectations raised by anti-angiogenic drugs …
and aberrant neovascularization. The initial expectations raised by anti-angiogenic drugs …
Effect of vascular normalization on drug delivery to different stages of tumor progression: In-silico analysis
Vascular normalization (VN) by anti-angiogenic factors may be efficacious for improving
drug delivery in solid tumors. In the present study, a 3D computational model is employed to …
drug delivery in solid tumors. In the present study, a 3D computational model is employed to …
[HTML][HTML] Hypoxia-induced therapy resistance: Available hypoxia-targeting strategies and current advances in head and neck cancer
VL Codony, M Tavassoli - Translational oncology, 2021 - Elsevier
Most solid tumors, such as head and neck cancers, feature a hypoxic microenvironment due
to angiogenic dysregulation and the consequent disruption of their vascular network. Such …
to angiogenic dysregulation and the consequent disruption of their vascular network. Such …
Perspectives on hypoxia signaling in tumor stroma
Y Zhang, M Coleman, RA Brekken - Cancers, 2021 - mdpi.com
Simple Summary Low oxygen tension (hypoxia) caused by high demand of cancer cell
proliferation or standard of care therapy is a prevalent feature of solid tumors and is often …
proliferation or standard of care therapy is a prevalent feature of solid tumors and is often …
[HTML][HTML] Predicting response to combination evofosfamide and immunotherapy under hypoxic conditions in murine models of colon cancer
The goal of this study is to develop a mathematical model that captures the interaction
between evofosfamide, immunotherapy, and the hypoxic landscape of the tumor in the …
between evofosfamide, immunotherapy, and the hypoxic landscape of the tumor in the …
Deep learning characterization of brain tumours with diffusion weighted imaging
Glioblastoma multiforme (GBM) is one of the most deadly forms of cancer. Methods of
characterizing these tumours are valuable for improving predictions of their progression and …
characterizing these tumours are valuable for improving predictions of their progression and …
Numerical investigation on the anti-angiogenic therapy-induced normalization in solid tumors
This study numerically analyzes the fluid flow and solute transport in a solid tumor to
comprehensively examine the consequence of normalization induced by anti-angiogenic …
comprehensively examine the consequence of normalization induced by anti-angiogenic …
Exploring chronic and transient tumor hypoxia for predicting the efficacy of hypoxia-activated pro-drugs
S Mathur, S Chen, KA Rejniak - NPJ Systems Biology and Applications, 2024 - nature.com
Hypoxia, a low level of oxygen in the tissue, arises due to an imbalance between the
vascular oxygen supply and oxygen demand by the surrounding cells. Typically, hypoxia is …
vascular oxygen supply and oxygen demand by the surrounding cells. Typically, hypoxia is …
Harnessing the Power of Nanomaterials to Alleviate Tumor Hypoxia in Favor of Cancer Therapy
Cancer hypoxia is considered a hallmark of almost all solid malignancy and is responsible
for diminishing the efficacy of some important cancer therapy modalities, particularly for …
for diminishing the efficacy of some important cancer therapy modalities, particularly for …