Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however,
remained enigmatic for a long time. Only within the past 10 years has the B-cell nature of the …

Abstract Hodgkin's and Reed/Sternberg (HRS) cells, the tumour cells in classical Hodgkin's
lymphoma (HL), represent transformed B cells in nearly all cases. The detection of …

Primary mediastinal large B-cell lymphoma (MLBCL) shares important clinical and
molecular features with classic Hodgkin lymphoma, including nuclear localization of the …

Hodgkin and Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (HL) and
lymphocytic and histiocytic (L&H) cells in nodular lymphocyte–predominant HL (NLPHL) are …

Death receptors belong to the tumor necrosis factor receptor superfamily and can induce
apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) …

Although the morphology of the pathognomonic Reed–Sternberg cells of Hodgkin
lymphoma (HL) was described over a century ago, it was not until recently that their origin …

Significant advances in the biology and treatment of Hodgkin lymphoma (HL) have been
accomplished over the past decades. In a landmark study, DeVita and colleagues showed …

According to the WHO classification, Hodgkin's lymphoma (HL) is subdivided into a classical
variant and a nodular lymphocyte predominant variant which are characterized by the …

Death receptors trigger apoptosis by activating the apical cysteine proteases caspase-8 and-
10 within a death-inducing signaling complex (DISC). c-FLIP (cellular FLICE inhibitory …

Abstract The malignant Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin
lymphoma (HL) are derived from mature B cells, but have lost a considerable part of the B …