Calcium is an abundant intracellular ion, and calcium homeostasis plays crucial roles in
several cellular processes. The calcineurin signaling cascade is one of the major pathways …

Candida glabrata is an opportunistic human fungal pathogen that causes superficial
mucosal and life-threatening bloodstream infections in individuals with a compromised …

The most enigmatic aspect of the rise of Candida auris as a human pathogen is that it
emerged simultaneously on three continents, with each clade being genetically distinct …

As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of
the innate immune response, and yet the commensal fungus Candida albicans is able to …

The opportunistic fungal pathogen Candida glabrata is a frequent cause of candidiasis,
causing infections ranging from superficial to life-threatening disseminated disease. The …

Eukaryotic transcription activators stimulate the expression of specific sets of target genes
through recruitment of co-activators such as the RNA polymerase II-interacting Mediator …

Many pathogenic fungi are dimorphic and switch between yeast and filamentous states. This
switch alters host-microbe interactions and is critical for pathogenicity. However, in …

Calcium ions are ubiquitous intracellular messengers. An increase in the cytosolic Ca2+
concentration activates many proteins, including calmodulin and the Ca2+/calmodulin …

Calcineurin is a highly conserved Ca2+/calmodulin-dependent serine/threonine-specific
protein phosphatase that orchestrates cellular Ca2+ signaling responses. In Cryptococcus …

Thermotolerance is a polygenic trait that contributes to cell survival and growth under
unusually high temperatures. Although some genes associated with high-temperature …