CD1: antigen presentation and T cell function
M Brigl, MB Brenner - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …
patterns of intracellular trafficking of CD1 molecules, and how they sample different …
Going both ways: immune regulation via CD1d-dependent NKT cells
DI Godfrey, M Kronenberg - The Journal of clinical …, 2004 - Am Soc Clin Investig
NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation
of immune responses associated with a broad range of diseases, including autoimmunity …
of immune responses associated with a broad range of diseases, including autoimmunity …
A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells
K Miyamoto, S Miyake, T Yamamura - Nature, 2001 - nature.com
Experimental autoimmune encephalomyelitis (EAE) is a prototype autoimmune disease
mediated by type 1 helper T (TH1) cells and under the control of regulatory cells,,. Here we …
mediated by type 1 helper T (TH1) cells and under the control of regulatory cells,,. Here we …
IL-10–producing NKT10 cells are a distinct regulatory invariant NKT cell subset
Invariant natural killer T (i NKT) cells rapidly produce copious amounts of multiple cytokines
after activation, thereby impacting a wide variety of different immune reactions. However …
after activation, thereby impacting a wide variety of different immune reactions. However …
Role of the innate immune system in the pathogenesis of multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with heterogeneous
clinical presentations and course. MS is considered to be a T cell mediated disease but in …
clinical presentations and course. MS is considered to be a T cell mediated disease but in …
Prolonged IFN-γ–producing NKT response induced with α-galactosylceramide–loaded DCs
S Fujii, K Shimizu, M Kronenberg, RM Steinman - Nature immunology, 2002 - nature.com
Natural killer T (NKT) lymphocytes mediate a rapid reaction to the glycolipid drug α-
galactosylceramide (αGalCer), which triggers release of large amounts of cytokines into the …
galactosylceramide (αGalCer), which triggers release of large amounts of cytokines into the …
The regulatory role of Vα14 NKT cells in innate and acquired immune response
M Taniguchi, M Harada, S Kojo… - Annual review of …, 2003 - annualreviews.org
A novel lymphocyte lineage, Vα14 natural killer T (NKT) cells, is now well established as
distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14 …
distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14 …
IL-25 regulates Th17 function in autoimmune inflammation
MA Kleinschek, AM Owyang, B Joyce-Shaikh… - The Journal of …, 2007 - rupress.org
Interleukin (IL)-25 is a member of the IL-17 family of cytokines. However, unlike the other
members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that IL-25 …
members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that IL-25 …
Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand α-galactosylceramide
α-Galactosylceramide (α-GalCer) is a glycolipid that stimulates natural killer T cells to
produce both T helper (Th) 1 and Th2 cytokines. This property enables α-GalCer to …
produce both T helper (Th) 1 and Th2 cytokines. This property enables α-GalCer to …
The innate immune system in demyelinating disease
L Mayo, FJ Quintana, HL Weiner - Immunological reviews, 2012 - Wiley Online Library
Demyelinating diseases such as multiple sclerosis are chronic inflammatory autoimmune
diseases with a heterogeneous clinical presentation and course. Both the adaptive and the …
diseases with a heterogeneous clinical presentation and course. Both the adaptive and the …