In the CNS, iron in several proteins is involved in many important processes such as oxygen
transportation, oxidative phosphorylation, myelin production, and the synthesis and …

Background: Restless legs syndrome is a common yet frequently undiagnosed sensorimotor
disorder. In 1995, the International Restless Legs Syndrome Study Group developed …

Background In 2003, following a workshop at the National Institutes of Health, the
International Restless Legs Syndrome Study Group (IRLSSG) developed updated …

Iron is the most abundant transition metal within the brain, and is vital for a number of
cellular processes including neurotransmitter synthesis, myelination of neurons, and …

Movement disorders, which include disorders such as Parkinson's disease, dystonia,
Tourette's syndrome, restless legs syndrome, and akathisia, have traditionally been …

Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a
wide range of physiologic and pathologic processes. In clinical medicine, ferritin is …

For the last century, there has been great physiological interest in brain iron and its role in
brain function and disease. It is well known that iron accumulates in the brain for people with …

Restless legs syndrome (RLS), also known as Willis–Ekbom Disease (WED), is a
sensorimotor disorder for which the exact pathophysiology remains unclear. Brain iron …

Sleep‐related disorders are most prevalent in the older adult population. A high prevalence
of medical and psychosocial comorbidities and the frequent use of multiple medications …

Decreased sleep duration and quality is associated with an increase in body weight and
adiposity. Insomnia, obstructive sleep apnea, and restless legs syndrome are three of the …