The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

In the course of chronic kidney disease (CKD), alterations in the bone-vascular axis
augment the risk of bone loss, fractures, vascular and soft tissue calcification, left ventricular …

Ferroptosis is a form of regulated cell death that involves metabolic dysfunction resulting
from iron-dependent excessive lipid peroxidation. Elevated plasma levels of free fatty acids …

Purpose: Osteoporosis is more likely to cause serious complications after joint replacement,
mainly due to physiological defects of endogenous osteogenic cells and the pathological …

Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells,
which can generate and sequester toxic reactive oxygen species (ROS) in response to …

Recent genome-wide association and transcriptome-wide association studies have
identified an association between the PALMD locus, encoding palmdelphin, a protein …

Biomaterial with the dual-functions of bone regeneration and antibacterial is a novel therapy
for infective bone defects. Three-dimensional (3D)-printed porous titanium (pTi) benefits …

Background: Vascular calcification is closely related to the all-cause mortality of
cardiovascular events. Basement membrane protein nidogen-2 is a key component of the …

Vascular Calcification (VC), low bone mass and fragility fractures are frequently observed in
ageing subjects. Although this clinical observation could be the mere coincidence of …

The serious complications after arthroplasty in patients with osteoporosis is a challenge for
orthopedics. Three-dimensional (3D)-printed porous titanium (pTi) alloys have the character …