Conflict in the Intracellular Lives of Endosymbionts and Viruses: A Mechanistic Look at Wolbachia-Mediated Pathogen-blocking
At the forefront of vector control efforts are strategies that leverage host-microbe associations
to reduce vectorial capacity. The most promising of these efforts employs Wolbachia, a …
to reduce vectorial capacity. The most promising of these efforts employs Wolbachia, a …
mi RNA s at the interface of cellular stress and disease
A Emde, E Hornstein - The EMBO journal, 2014 - embopress.org
Abstract microRNAs (miRNAs) are a family of small, non‐coding RNAs, which provides
broad silencing activity of mRNA targets in a sequence‐dependent fashion. This review …
broad silencing activity of mRNA targets in a sequence‐dependent fashion. This review …
Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila
JG Wood, BC Jones, N Jiang… - Proceedings of the …, 2016 - National Acad Sciences
Transposable elements (TEs) are mobile genetic elements, highly enriched in
heterochromatin, that constitute a large percentage of the DNA content of eukaryotic …
heterochromatin, that constitute a large percentage of the DNA content of eukaryotic …
Broad RNA interference–mediated antiviral immunity and virus-specific inducible responses in Drosophila
The fruit fly Drosophila melanogaster is a good model to unravel the molecular mechanisms
of innate immunity and has led to some important discoveries about the sensing and …
of innate immunity and has led to some important discoveries about the sensing and …
Activation of transposable elements during aging and neuronal decline in Drosophila
W Li, L Prazak, N Chatterjee, S Grüninger, L Krug… - Nature …, 2013 - nature.com
We found that several transposable elements were highly active in Drosophila brain during
normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) …
normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) …
[HTML][HTML] The RNA methyltransferase Dnmt2 is required for efficient Dicer-2-dependent siRNA pathway activity in Drosophila
Z Durdevic, MB Mobin, K Hanna, F Lyko, M Schaefer - Cell reports, 2013 - cell.com
Transfer RNA (tRNA) fragmentation in response to stress conditions has been described in
many organisms. tRNA fragments have been found in association with small interfering RNA …
many organisms. tRNA fragments have been found in association with small interfering RNA …
Endogenous siRNAs: regulators of internal affairs
MJ Piatek, A Werner - Biochemical Society Transactions, 2014 - portlandpress.com
Endo-siRNAs (endogenous small-interfering RNAs) have recently emerged as versatile
regulators of gene expression. They derive from double-stranded intrinsic transcripts and …
regulators of gene expression. They derive from double-stranded intrinsic transcripts and …
Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila
J Rigal, AM Anduaga, E Bitman, E Rivellese… - Elife, 2022 - elifesciences.org
Transposable elements (TEs) are mobile sequences of DNA that can become
transcriptionally active as an animal ages. Whether TE activity is simply a by-product of …
transcriptionally active as an animal ages. Whether TE activity is simply a by-product of …
Defense Mechanisms against Viral Infection in Drosophila: RNAi and Non-RNAi
RNAi is considered a major antiviral defense mechanism in insects, but its relative
importance as compared to other antiviral pathways has not been evaluated …
importance as compared to other antiviral pathways has not been evaluated …
Sensing and signalling viral infection in drosophila
J Schneider, JL Imler - Developmental & Comparative Immunology, 2021 - Elsevier
The fruitfly Drosophila melanogaster is a valuable model to unravel mechanisms of innate
immunity, in particular in the context of viral infections. RNA interference, and more …
immunity, in particular in the context of viral infections. RNA interference, and more …