Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …

Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

Neutrophils respond to myocardial ischemia–reperfusion in a manner similar to the bacterial
invasion of a host. The inflammatory-like response that follows the onset of reperfusion …

Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic
modulator and also as a neuromodulator at the synaptic level. We will present evidence to …

Reperfusion of ischemic myocardium is necessary to salvage tissue from eventual death.
However, reperfusion after even brief periods of ischemia is associated with pathologic …

Abstract OBJECTIVES The Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial
was designed to test the hypothesis that adenosine as an adjunct to thrombolysis would …

Adenosine accumulation during ischemia and inflammation protects tissues from injury. In
ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …