Although dopamine replacement therapy remains a core component of Parkinson's disease
treatment, the onset of motor fluctuations and dyskinetic movements might require a range of …

Parkinson's disease (PD) is an alpha-synucleinopathy that leads to prominent motor
symptoms including tremor, bradykinesia, and postural instability. Nonmotor symptoms …

Slow-wave sleep (SWS) modulation in rodent models of Alzheimer's disease alters
extracellular amyloid burden. In Parkinson's disease (PD), SWS appears to be closely linked …

Parkinson's disease (PD) is a complex, multisystem disorder with both neurologic and
systemic manifestations, which is usually associated with non-motor symptoms, including …

Introduction: This systematic review provides supporting evidence for the accompanying
clinical practice guideline on the treatment of central disorders of hypersomnolence in adults …

There are numerous disorders of known or presumed neurologic origin that result in
excessive daytime sleepiness, collectively known as the central disorders of …

There is increasing interest in the effects of sleep and sleep disturbances on the brain,
particularly in relation to aging and neurodegenerative processes. Parkinson disease (PD) …

Parkinson disease (PD) is the second most common neurodegenerative disease. Up to 98%
of PD patients report experiencing at least one non-motor symptom (NMS) 1, 2, among …

Parkinson's disease (PD) is defined by its motor symptoms rigidity, tremor, and akinesia.
However, non-motor symptoms, particularly autonomic disorders and sleep disturbances …

Excessive daytime sleepiness (EDS) and fatigue are some of the most frequent symptoms in
neurological diseases and could impact on quality of life by increasing the risk of accidents …