The spatial distribution of chromatin domains in interphase nuclei changes dramatically
during development in multicellular organisms. A crucial question is whether nuclear …

Understanding the plasticity of genomes has been greatly aided by assays for
recombination, repair and mutagenesis. These assays have been developed in microbial …

Homologous recombination, an essential process for preserving genomic integrity, uses
intact homologous sequences to repair broken chromosomes. To explore the mechanism of …

Chromatin mobility is thought to facilitate homology search during homologous
recombination and to shift damage either towards or away from specialized repair …

Nuclear pore complexes (NPCs) have increasingly recognized interactions with the
genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By …

Persistent DNA double-strand breaks (DSBs) are recruited to the nuclear periphery in
budding yeast. Both the Nup84 pore subcomplex and Mps3, an inner nuclear membrane …

In this paper we show that tethering of heterochromatic regions to nuclear landmarks and
random encounters of chromosomes in the confined nuclear volume are sufficient to explain …

Chromatin in the interphase nucleus moves in a constrained random walk. Despite
extensive study, the molecular causes of such movement and its impact on DNA-based …

To understand whether the spatial organization of the genome reflects the cell's
differentiated state, we examined whether genes assume specific subnuclear positions …

High-resolution imaging shows that persistent DNA damage in budding yeast localizes in
distinct perinuclear foci for repair. The signals that trigger DNA double-strand break (DSB) …