Genetic predisposition and chromosome instability in neuroblastoma

GP Tonini, M Capasso - Cancer and Metastasis Reviews, 2020 - Springer
Neuroblastoma (NB) is a pediatric tumor of embryonic origin. About 1–2% of all NBs are
familial cases, and genetic predisposition is suspected for the remaining cases. During the …

Genetic susceptibility to neuroblastoma: current knowledge and future directions

LE Ritenour, MP Randall, KR Bosse, SJ Diskin - Cell and tissue research, 2018 - Springer
Neuroblastoma, a malignancy of the developing peripheral nervous system that affects
infants and young children, is a complex genetic disease. Over the past two decades …

[HTML][HTML] Metastasis as a systemic disease: molecular insights and clinical implications

M Alečković, SS McAllister, K Polyak - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
Metastasis is a complex systemic disease that develops as a result of interactions between
tumor cells and their local and distant microenvironments. Local and systemic immune …

MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

R Dhanasekaran, V Baylot, M Kim, S Kuruvilla… - Elife, 2020 - elifesciences.org
Metastasis is a major cause of cancer mortality. We generated an autochthonous transgenic
mouse model whereby conditional expression of MYC and Twist1 enables hepatocellular …

Zebrafish-based platform for emerging bio-contaminants and virus inactivation research

P Patel, A Nandi, SK Verma, N Kaushik, M Suar… - Science of The Total …, 2023 - Elsevier
Emerging bio-contaminants such as viruses have affected health and environment settings
of every country. Viruses are the minuscule entities resulting in severe contagious diseases …

CKLF instigates a “cold” microenvironment to promote MYCN-mediated tumor aggressiveness

X Qin, A Lam, X Zhang, S Sengupta, JB Iorgulescu… - Science …, 2024 - science.org
Solid tumors, especially those with aberrant MYCN activation, often harbor an
immunosuppressive microenvironment to fuel malignant growth and trigger treatment …

The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression

Y Qian, L Zhang, M Cai, H Li, H Xu, H Yang, Z Zhao… - Science …, 2019 - science.org
Genome-wide association studies identified single-nucleotide polymorphism (SNP)
rs55958994 as a significant variant associated with increased susceptibility to prostate …

Single-cell RNA-seq reveals the transcriptional program underlying tumor progression and metastasis in neuroblastoma

Z Nian, D Wang, H Wang, W Liu, Z Ma, J Yan, Y Cao… - Frontiers of …, 2024 - Springer
Neuroblastoma (NB) is one of the most common childhood malignancies. Sixty percent of
patients present with widely disseminated clinical signs at diagnosis and exhibit poor …

[HTML][HTML] MYCN-mediated regulation of the HES1 promoter enhances the chemoresistance of small-cell lung cancer by modulating apoptosis

Q Tong, S Ouyang, R Chen, J Huang… - American Journal of …, 2019 - ncbi.nlm.nih.gov
MYCN, a member of the MYC family, is correlated with tumorigenesis, metastasis and
therapy in many malignancies; however, its role in small-cell lung cancer (SCLC) remains …

Ethyl acetate fraction from Hedyotis Diffusa plus Scutellaria Barbata inhibits the progression of breast cancer via targeting LMO1 and AKT/Mtor Signaling pathway

Z Li, J Li, X Liu, Z Sun, X Sun - Combinatorial Chemistry & High …, 2024 - ingentaconnect.com
Background: Traditional Chinese medicines are widely used in cancer treatment. Scutellaria
barbata and Hedyotis diffusa herb pair (SH) has an anticancer effects in various tumors …