Prolactin has a rich mechanistic set of actions and signaling in order to elicit developmental
effects in mammals. Historically, prolactin has been appreciated as an endocrine peptide …

Gap junctions, membrane-based channels comprised of connexin proteins (Cxs), facilitate
direct communication among neighbouring cells and between cells and the extracellular …

In vitro cancer cell cultures are facile experimental models used widely for research and
drug development. Many cancer cell lines are available and efforts are ongoing to derive …

The earliest mammalian cell lines, established by Earle et al. in 1943, were derived from the
subcutaneous tissue of a C3H mouse strain and many cell lines still used today were …

Most therapeutic agents used for treating brain malignancies face hindered transport
through the blood–brain barrier (BBB) and poor tissue penetration. To overcome these …

Targeting the supportive tumor microenvironment (TME) is an approach of high interest in
cancer drug development. However, assessing TME-targeted drug candidates presents a …

Cell lines are essential models for biomedical research. However, they have a common and
important problem that needs to be addressed. Cell lines can be misidentified, meaning that …

Uveal Melanoma (UM) is a rare disease, yet it is the most common primary intraocular
malignancy in adult patients. Despite continuous advancements and research, the risk of …

Polymeric biomaterials have been used in a variety of applications, like cargo delivery and
tissue scaffolding, because they are easily synthesized and can be adapted to many …

Metastatic melanoma has a very poor prognosis. Statins, 3-hydroxy-3-methyl-glutaryl-
coenzyme A reductase (HMGCR) inhibitors, are cholesterol-lowering agents with a potential …