The interplay between tumor suppressor p53 and hypoxia signaling pathways in cancer
Hypoxia is a hallmark of solid tumors and plays a critical role in different steps of tumor
progression, including proliferation, survival, angiogenesis, metastasis, metabolic …
progression, including proliferation, survival, angiogenesis, metastasis, metabolic …
The role of vascular endothelial growth factor in pulmonary arterial hypertension. The angiogenesis paradox
NF Voelkel, J Gomez-Arroyo - American journal of respiratory cell …, 2014 - atsjournals.org
Pulmonary arterial hypertension (PAH) is characterized by dysfunctional angiogenesis
leading to lung vessel obliteration. PAH is widely considered a proangiogenic disease; …
leading to lung vessel obliteration. PAH is widely considered a proangiogenic disease; …
Extracellular vesicles derived from hypoxia-preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR-612
L Ge, C Xun, W Li, S Jin, Z Liu, Y Zhuo, D Duan… - Journal of …, 2021 - Springer
Mesenchymal stem cells (MSCs) play important roles in tissue repair and regeneration, such
as the induction of angiogenesis, particularly under hypoxic conditions. However, the …
as the induction of angiogenesis, particularly under hypoxic conditions. However, the …
[图书][B] Cancer: principles & practice of oncology: primer of the molecular biology of cancer
VT DeVita, VT DeVita Jr, TS Lawrence, SA Rosenberg - 2011 - books.google.com
Drawn from the content of the new Ninth Edition of Cancer: Principles and Practice of
Oncology, this unique publication brings together the basic scientific information on the …
Oncology, this unique publication brings together the basic scientific information on the …
Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension
S Isobe, RV Nair, HY Kang, L Wang… - Nature …, 2023 - nature.com
Pulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial
(PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 …
(PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 …
Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis
H Huang, AY Chen, Y Rojanasakul, X Ye… - Journal of functional …, 2015 - Elsevier
Galangin and myricetin are flavonoids isolated from vegetables and fruits which exhibit anti-
proliferative activity in human cancer cells. In this study, their anti-angiogenic effects were …
proliferative activity in human cancer cells. In this study, their anti-angiogenic effects were …
Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer
Abstract The plant Sophora flavescens Ait. has been used in the clinical management of
colorectal cancer (CRC). Its constituent compounds, notably the alkaloids matrine …
colorectal cancer (CRC). Its constituent compounds, notably the alkaloids matrine …
Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy
Q Sun, J Zhou, Z Zhang, M Guo, J Liang… - Cancer Biology & …, 2014 - Taylor & Francis
VEGF/VEGFR signal axis has been proven to be an important target for development of
novel cancer therapies. One challenging aspect in small molecular VEGFR inhibitors is to …
novel cancer therapies. One challenging aspect in small molecular VEGFR inhibitors is to …
Anticancer effect of deuterium depleted water-redox disbalance leads to oxidative stress
X Zhang, M Gaetani, A Chernobrovkin… - Molecular & Cellular …, 2019 - ASBMB
Despite the convincing empirical evidence that deuterium depleted water (DDW, 25–125
ppm deuterium) has anticancer effect, the molecular mechanism remains unclear. Here …
ppm deuterium) has anticancer effect, the molecular mechanism remains unclear. Here …