Tumor development is a complex process resulting from interplay between mutations in
oncogenes and tumor suppressors, host susceptibility factors, and cellular context. Great …

Purpose To define copy number alterations and gene expression signatures underlying
pediatric high-grade glioma (HGG). Patients and Methods We conducted a high-resolution …

Ewing sarcoma is an aggressive neoplasm occurring predominantly in adolescent
Caucasians. At the genome level, a pathognomonic EWSR1-ETS translocation is present …

Background Co-expression correlations provide the ability to predict gene functionality
within specific biological contexts, such as different tissue and disease conditions. However …

Adverse prognosis in Ewing sarcoma (ES) is associated with the presence of metastases,
particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic …

Multi-agent chemotherapeutic regimes remain the cornerstone treatment for Ewing sarcoma,
the second most common bone malignancy diagnosed in pediatric and young adolescent …

Connections between epigenetic reprogramming and transcription or splicing create novel
mechanistic networks that can be targeted with tailored therapies. Multiple subunits of the …

Despite extensive characterization of the role of the EWS-ETS fusions, little is known about
secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has …

The molecular hallmark of the Ewing's family of tumors is the presence of balanced
chromosomal translocations, leading to the formation of chimerical transcription factors (that …

Using an integrative genomics approach called amplification breakpoint ranking and
assembly analysis, we nominated KRAS as a gene fusion with the ubiquitin-conjugating …