Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an
uncommon drug adverse reaction that can develop to conditions spanning from …

Obesity-induced chronic liver inflammation is a hallmark of nonalcoholic steatohepatitis
(NASH)—an aggressive form of nonalcoholic fatty liver disease. However, it remains unclear …

Various factors, including viral and bacterial infections, autoimmune responses, diabetes,
drugs, alcohol abuse, and fat deposition, can damage liver tissue and impair its function …

Inflammaging, characterized by an increase in low‐grade chronic inflammation with age, is a
hallmark of aging and is strongly associated with various age‐related diseases, including …

Background Glioblastoma (GB) is the most common and highly malignant brain tumor
characterized by aggressive growth and resistance to alkylating chemotherapy. Autophagy …

High-mobility group box-1 (HMGB1), a ubiquitous nuclear protein, acts as a late mediator of
lethality when released extracellularly during sepsis. The major source of circulating HMGB1 …

Acetaminophen overdose is a leading cause of acute live failure worldwide. N-
acetylcysteine (NAC), as the only antidote, is limited due to its narrow therapeutic time …

Nonalcoholic steatohepatitis, one of the most common chronic liver diseases, is a
progressive form of nonalcoholic fatty liver disease accompanied by the development of liver …

The liver is an important metabolic organ, and acute liver injury (ALI) is potentially lethal.
Itaconate, a metabolic intermediate from the tricarboxylic acid cycle, showed emerging anti …

Epilepsy is a serious neurological condition exhibiting complex pathology and deserving of
more serious attention. More than 30% of people with epilepsy are not responsive to more …