Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation

R Bai, C Yao, Z Zhong, J Ge, Z Bai, X Ye, T Xie… - European Journal of …, 2021 - Elsevier
Inflammation is an adaptive response of the immune system to tissue malfunction or
homeostatic imbalance. Corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) …

Plant-derived alkaloids: the promising disease-modifying agents for inflammatory bowel disease

J Peng, TT Zheng, X Li, Y Liang, LJ Wang… - Frontiers in …, 2019 - frontiersin.org
Inflammatory bowel disease (IBD) represents a group of intestinal disorders with self-
destructive and chronic inflammation in the digestive tract, requiring long-term medications …

The influence of alkaloids on oxidative stress and related signaling pathways

K Macáková, R Afonso, L Saso, P Mladěnka - Free Radical Biology and …, 2019 - Elsevier
Alkaloids have always attracted scientific interest due to either their positive or negative
effects on human beings. This review aims to summarize their antioxidant effects by both …

Treatment effects of natural products on inflammatory bowel disease in vivo and their mechanisms: Based on animal experiments

Y Zhou, D Wang, W Yan - Nutrients, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory disease of the
intestine that can be classified as ulcerative colitis (UC) and Crohn's disease (CD) …

Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS‐Induced Neuroinflammation by Interfering in the TLR4/NF‐κB‐MAPK Signaling Pathway …

JAC de Sousa, FVCS Azul, AB de Araújo… - Oxidative Medicine …, 2023 - Wiley Online Library
Neuroinflammation is present in the pathophysiological mechanisms of several diseases
that affect the central nervous system (CNS). Microglia have a prominent role in initiating …

Probiotic Bacillus licheniformis MCC2514 and Bifidobacterium breve NCIM 5671 Regulates GATA3 and Foxp3 Expression in the Elevated Disease Condition

HS Rohith, MS Peddha, PM Halami - Probiotics and Antimicrobial Proteins, 2024 - Springer
TNBS-induced ulcerative colitis was evaluated using Bacillus licheniformis MCC 2514 (B.
licheniformis) and Bifidobacterium breve NCIM 5671 (Bf. breve) as immune modulators. The …

Anatabine attenuates ovalbumin-induced asthma via oxidative stress and inflammation mitigation and Nrf2/HO-1 signaling upregulation in rats

W Abdo, I Haziri, M Dmerdash, SM Alnasser, A Hakamy… - Life Sciences, 2022 - Elsevier
Aims Asthma affects a large number of people worldwide and is characterized by chronic
allergic airway inflammation. Anatabine is a natural alkaloid that is structurally similar to …

Development of an Advanced Multicellular Intestinal Model for Assessing Immunomodulatory Properties of Anti-Inflammatory Compounds

D Marescotti, G Lo Sasso, D Guerrera… - Frontiers in …, 2021 - frontiersin.org
Intestinal inflammation is the collective term for immune system-mediated diseases of
unknown, multifactorial etiology, with often complex interactions between genetic and …

Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis

PA Ruiz Castro, U Kogel, G Lo Sasso, BW Phillips… - Journal of …, 2020 - Springer
Background Inflammatory bowel disease (IBD) is the collective term for chronic immune-
mediated diseases of unknown, multifactorial etiology, arising from the interplay between …

[HTML][HTML] Thymol has beneficial effects on the experimental model of ulcerative colitis

P Tahmasebi, SMA Froushani… - Avicenna journal of …, 2019 - ncbi.nlm.nih.gov
Objective: Thymol, a natural aromatic monoterpene phenol derived from thymus, possesses
anti-inflammatory benefits. Here, we evaluated the potential of thymol therapy in improving …