Mechanisms and models of cardiac sodium channel inactivation
KE Mangold, BD Brumback, P Angsutararux… - Channels, 2017 - Taylor & Francis
Shortly after cardiac Na+ channels activate and initiate the action potential, inactivation
ensues within milliseconds, attenuating the peak Na+ current, INa, and allowing the cell …
ensues within milliseconds, attenuating the peak Na+ current, INa, and allowing the cell …
Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation
P Angsutararux, PW Kang, W Zhu… - Journal of General …, 2021 - rupress.org
Voltage-gated Na+ (NaV) channels underlie the initiation and propagation of action
potentials (APs). Rapid inactivation after NaV channel opening, known as open-state …
potentials (APs). Rapid inactivation after NaV channel opening, known as open-state …
Predicting patient response to the antiarrhythmic mexiletine based on genetic variation: personalized medicine for long QT syndrome
Rationale: Mutations in the SCN5A gene, encoding the α subunit of the Nav1. 5 channel,
cause a life-threatening form of cardiac arrhythmia, long QT syndrome type 3 (LQT3) …
cause a life-threatening form of cardiac arrhythmia, long QT syndrome type 3 (LQT3) …
Molecular pathology of sodium channel beta-subunit variants
P Angsutararux, W Zhu, TL Voelker… - Frontiers in …, 2021 - frontiersin.org
The voltage-gated Na+ channel regulates the initiation and propagation of the action
potential in excitable cells. The major cardiac isoform NaV1. 5, encoded by SCN5A …
potential in excitable cells. The major cardiac isoform NaV1. 5, encoded by SCN5A …
Mechanisms of noncovalent β subunit regulation of NaV channel gating
Voltage-gated Na+ (NaV) channels comprise a macromolecular complex whose
components tailor channel function. Key components are the non-covalently bound β1 and …
components tailor channel function. Key components are the non-covalently bound β1 and …
Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms
BM Bohannon, A de la Cruz, X Wu, JJ Jowais… - Elife, 2020 - elifesciences.org
The cardiac ventricular action potential depends on several voltage-gated ion channels,
including NaV, CaV, and KV channels. Mutations in these channels can cause Long QT …
including NaV, CaV, and KV channels. Mutations in these channels can cause Long QT …
[HTML][HTML] Modulation of the effects of class Ib antiarrhythmics on cardiac NaV1. 5-encoded channels by accessory NaVβ subunits
Native myocardial voltage-gated sodium (Na V) channels function in macromolecular
complexes comprising a pore-forming (α) subunit and multiple accessory proteins. Here, we …
complexes comprising a pore-forming (α) subunit and multiple accessory proteins. Here, we …
Conservation and divergence in NaChBac and NaV1.7 pharmacology reveals novel drug interaction mechanisms
Abstract Voltage-gated Na+ (NaV) channels regulate homeostasis in bacteria and control
membrane electrical excitability in mammals. Compared to their mammalian counterparts …
membrane electrical excitability in mammals. Compared to their mammalian counterparts …
Identification of structures for ion channel kinetic models
KE Mangold, W Wang, EK Johnson… - PLoS computational …, 2021 - journals.plos.org
Markov models of ion channel dynamics have evolved as experimental advances have
improved our understanding of channel function. Past studies have examined limited sets of …
improved our understanding of channel function. Past studies have examined limited sets of …
A Molecularly Detailed NaV1.5 Model Reveals a New Class I Antiarrhythmic Target
Antiarrhythmic treatment strategies remain suboptimal due to our inability to predict how
drug interactions with ion channels will affect the ability of the tissues to initiate and sustain …
drug interactions with ion channels will affect the ability of the tissues to initiate and sustain …