Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Opportunities in cancer therapies: Deciphering the role of cancer stem cells in tumour repopulation

LG Marcu, M Dell'Oro, E Bezak - International Journal of Molecular …, 2023 - mdpi.com
Tumour repopulation during treatment is a well acknowledged yet still challenging aspect of
cancer management. The latest research results show clear evidence towards the existence …

SIX1 amplification modulates stemness and tumorigenesis in breast cancer

L Guo, F Li, H Liu, D Kong, C Chen, S Sun - Journal of Translational …, 2023 - Springer
Background Sine oculis homeobox homolog 1 (SIX1) is a transcription factor that has
recently been identified as a crucial regulator of embryonic development and tumorigenesis …

P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker

Z Yuan, H Jing, Y Deng, M Liu, T Jiang, X Jin, W Lin… - Oncogenesis, 2024 - nature.com
Glioblastoma stem cells (GSCs) are pivotal in the recurrence and drug resistance of
glioblastoma multiforme (GBM). However, precision therapeutic and diagnostic markers for …

Functional prediction of response to therapy prior to therapeutic intervention is associated with improved survival in patients with high-grade glioma

A Ledford, A Rodriguez, L Lipinski, A Abad… - Scientific reports, 2024 - nature.com
Patients with high-grade glioma (HGG) have an extremely poor prognosis compounded by a
lack of advancement in clinical care over the past few decades. Regardless of classification …

Challenging the status quo to improve the translational potential of preclinical oncology studies

K Connor, A Golebiewska, AT Byrne - Nature Reviews Cancer, 2024 - nature.com
The precision medicine era has precipitated inherent new challenges to the preclinical
tumour biology field. Overall, continued poor clinical translatability of preclinical studies …

Cancer stem cells as a therapeutic target: current clinical development and future prospective

A Philchenkov, A Dubrovska - Stem Cells, 2024 - academic.oup.com
The key role of cancer stem cells (CSCs) in tumor development and therapy resistance
makes them essential biomarkers and therapeutic targets. Numerous agents targeting …

Construction of Biomimetic Camouflaged Neutrophil Membrane Nanoparticles for Precise Delivery and Augmented Glioma Cancer Treatment

Y Bi, P Qian, Z Su, W Dai, F Xu, C Luo - Process Biochemistry, 2024 - Elsevier
Developing novel nanomedicine formulations that successfully penetrate the blood-brain
barrier (BBB) to treat and diagnose glioma effectively is still a significant obstacle. This study …

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

M Habeeb, HT Vengateswaran, HW You… - Journal of Materials …, 2024 - pubs.rsc.org
Glioblastoma (GBM) is a highly aggressive and lethal type of brain tumor with complex and
diverse molecular signaling pathways involved that are in its development and progression …

[HTML][HTML] Methods for Overcoming Chemoresistance in Head and Neck Squamous Cell Carcinoma: Keeping the Focus on Cancer Stem Cells, a Systematic Review

ME Bizzoca, VCA Caponio, L Lo Muzio, PP Claudio… - Cancers, 2024 - mdpi.com
Simple Summary Head and Neck Cancer is often diagnosed at an advanced stage, resulting
in poor long-term prognosis. Additionally, this cancer is resistant to chemotherapy. This …