As well as being considered a reliable measurement instrument of animal anxiety-like
behavior, the elevated plus-maze (EPM) is also used as a post-hoc test to evaluate …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Appropriate processing of reward and aversive information is essential for survival. Although
a critical role of serotonergic neurons in the dorsal raphe nucleus (DRN) in reward …

Abstract The serotonin transporter (5-HTT) regulates serotonergic neurotransmission via
clearance of extracellular serotonin. Abnormalities in 5-HTT expression or function are found …

Background: Postweaning social isolation in rats produces profound and long‐lasting
cognitive and behavioral deficits in adult animals. Importantly, this housing manipulation …

A multitude of mechanisms are involved in the control of emotion and in the response to
stress. These incorporate mediators/targets as diverse as γ-aminobutyric acid (GABA) …

▪ Abstract Anxiety and its disorders have long been known to be familial. Recently, genetic
approaches have been used to clarify the role of heredity in the development of anxiety and …

Although the role of the median raphe nucleus (MRN) in the regulation of anxiety has
received less attention than that of the dorsal raphe nucleus (DRN) there is substantial …

The role of individual factors in behavioral neuroscience is an important, but still neglected,
area of research. For example, the Elevated Plus-Maze Test has been one of the most used …

A single undrugged experience of the elevated plus-maze modifies future drug responses in
the test. The present study investigated the effects of maze-experience on the acute …