The Mediator complex as a master regulator of transcription by RNA polymerase II
WF Richter, S Nayak, J Iwasa, DJ Taatjes - Nature Reviews Molecular …, 2022 - nature.com
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
Optical tweezers in single-molecule biophysics
CJ Bustamante, YR Chemla, S Liu… - Nature Reviews Methods …, 2021 - nature.com
Optical tweezers have become the method of choice in single-molecule manipulation
studies. In this Primer, we first review the physical principles of optical tweezers and the …
studies. In this Primer, we first review the physical principles of optical tweezers and the …
Causes and consequences of RNA polymerase II stalling during transcript elongation
M Noe Gonzalez, D Blears, JQ Svejstrup - Nature reviews Molecular …, 2021 - nature.com
The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains
In mammals, HP1-mediated heterochromatin forms positionally and mechanically stable
genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ …
genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ …
A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery
In prokaryotes, translation can occur on mRNA that is being transcribed in a process called
coupling. How the ribosome affects the RNA polymerase (RNAP) during coupling is not well …
coupling. How the ribosome affects the RNA polymerase (RNAP) during coupling is not well …
Real-time observation of transcription initiation and elongation on an endogenous yeast gene
Cellular messenger RNA levels are achieved by the combinatorial complexity of factors
controlling transcription, yet the small number of molecules involved in these pathways …
controlling transcription, yet the small number of molecules involved in these pathways …
Genetic variability of human respiratory syncytial virus A strains circulating in Ontario: a novel genotype with a 72 nucleotide G gene duplication
AR Eshaghi, VR Duvvuri, R Lai, JT Nadarajah, A Li… - PloS one, 2012 - journals.plos.org
Human respiratory syncytial virus (HRSV) is the main cause of acute lower respiratory
infections in children under 2 years of age and causes repeated infections throughout life …
infections in children under 2 years of age and causes repeated infections throughout life …
Transcription under torsion
J Ma, L Bai, MD Wang - Science, 2013 - science.org
In cells, RNA polymerase (RNAP) must transcribe supercoiled DNA, whose torsional state is
constantly changing, but how RNAP deals with DNA supercoiling remains elusive. We report …
constantly changing, but how RNAP deals with DNA supercoiling remains elusive. We report …