Planarians as a model to study neurotoxic agents

D Ireland, EMS Collins - Advances in Neurotoxicology, 2023 - Elsevier
The developing brain is more vulnerable to chemicals than the adult brain, but
environmental chemicals have only been sparingly tested for developmental neurotoxicity …

[HTML][HTML] Unveiling the Subtle Threats: The Neurobehavioral Impact of Chlorpyrifos on Girardia tigrina

AS Saraiva, EB Reis, FS Farnese, MS Oliveira… - Toxics, 2024 - mdpi.com
Chlorpyrifos, an organophosphate insecticide widely used to control agricultural pests,
poses a significant environmental threat due to its toxicity and persistence in soil and water …

The Role of Polycystic Kidney Disease-like Homologs in planarian Nervous System Regeneration and Function

KG Ross, SA Zepeda, MA Auwal… - Integrative …, 2024 - academic.oup.com
Planarians are an excellent model for investigating molecular mechanisms necessary for
regenerating a functional nervous system. Numerous studies have led to the generation of …

Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planarians

D Ireland, CS Rabeler, SS Rao, RJ Richardson… - bioRxiv, 2024 - biorxiv.org
Mental illnesses put a tremendous burden on afflicted individuals and society. Identification
of novel drugs to treat such conditions is intrinsically challenging due to the complexity of …

[PDF][PDF] The multiscale wisdom of the body: collective intelligence as a tractable interface

M Levin - Physiological Reviews - osf.io
The dominant paradigm in biomedicine focuses on the genetically-specified components of
cells, and their biochemical dynamics. This perspective emphasizes bottom-up emergence …

The Role of POU4-2 in Mechanosensory Neuron Function and Regeneration in Planarians

RA McCubbin - 2022 - search.proquest.com
The POU domain class IV family of transcription factors play essential roles in cellular
differentiation and neural development, but its function in a regenerative context has not …

Analysis of Ion Channels in Planarian Behavior and Sensory Neuron Regeneration

AK Garces - 2022 - search.proquest.com
Sensory neurons participate in diverse functions to allow external stimuli to be perceived
across all organisms. Specialized ion channels expressed in sensory neurons are important …