Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

Background There has been increasing interest in cortical microstructure as a
complementary and earlier measure of neurodegeneration than macrostructural atrophy, but …

Pathological cerebral white matter changes in Alzheimer's disease have been shown using
diffusion tensor imaging. Superficial white matter changes are relatively understudied …

The aim of this research was to test a novel in‐vivo brain MRI analysis method that could be
used in clinical cohorts to investigate cortical architecture changes in patients with …

Objective Multimodal imaging techniques have furthered our understanding of how different
aspects of Alzheimer's disease (AD) pathology relate to one another. Diffusion tensor …

Objective To investigate cortical microstructural measures from diffusion MRI as
“neurodegeneration” markers that could improve prognostic accuracy in mild cognitive …

Background Alzheimer's disease (AD) neuropathology reveals progressive microstructural
alterations of cortical architecture. Recent studies reported intriguing biphasic trajectories of …

Concussive head injury (CHI) is one of the major risk factors in developing Alzheimer's
disease (AD) in military personnel at later stages of life. Breakdown of the blood–brain …

Background Frontotemporal lobar degeneration (FTLD) is a neuropathological construct
with multiple clinical presentations, including the behavioural variant of frontotemporal …

Abstract Background Soluble Amyloid-beta (Aβ) oligomers are thought to play a key role in
the pathogenesis of Alzheimer's disease (AD), which is the most common age-associated …