Leptin-melanocortin pathway plays an essential role in the body weight regulation.
Enhanced melanocortin signaling in the hypothalamus results in both decreased food intake …

Context The melanocortin-4 receptor gene (MC4R) is associated with a higher risk of obesity
by the presence of the C allele in rs17782313, but the mechanisms are not clear. Objective …

Numerous studies have identified the various fat mass and obesity-associated (FTO) genetic
variants associated with obesity and its metabolic consequences; however, the impact of …

The function of long non-coding RNA (lncRNA) can be achieved through the regulation of
target genes, and the deposition of fat is regulated by lncRNA. Fat has an important effect on …

Melanocortin 4 receptor (MC4R), a notable component of the melanocortin system,
regulates appetite, body weight, and energy homeostasis. Genome-wide association studies …

Some common single-nucleotide polymorphisms of the brain-derived neurotrophic factor
(BDNF) gene have been associated not only with the neurodegenerative diseases but also …

This population-based longitudinal study is the first investigation that assesses the
association of common MC4R SNPs with the obesity-related parameters over time and …

Transcription factor-7–like 2 (TCF7L2) is one of the most important susceptibility genes for
type 2 diabetes mellitus (T2DM). The aim of our cross-sectional population-based study was …

Background Research shows that part of the variation in physical activity and sedentary
behaviour may be explained by genetic factors. Identifying genetic variants associated with …

Prediabetes is an intermediate state of hyperglycemia during which glycemic parameters
are above normal levels but below the T2D threshold. T2D and its precursor prediabetes …