Human induced pluripotent stem cells (iPSCs) can be limitlessly expanded and
differentiated into almost all cell types. Moreover, they are amenable to gene manipulation …

Liver transplantation is the most common treatment for patients suffering from liver failure
that is caused by congenital diseases, infectious agents, and environmental factors. Despite …

Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be
achieved without chronic immunosuppression or encapsulation. Existing genetic …

Refractoriness to platelet transfusion is a major problem in a small group of patients, and
large-scale manufacturing of clinical grade functional platelets ex vivo has remained an …

Osteoarthritis is a leading cause of pain and joint immobility, the incidence of which is
increasing worldwide. Currently, total joint replacement is the only treatment for end-stage …

Abstract Purpose of Review Human pluripotent stem cells have the potential to revolutionize
the treatment of inborn and degenerative diseases, including aging and autoimmunity. A …

Platelets are anucleate blood cells produced from megakaryocytes predominantly in the
bone marrow and released into blood circulation at a healthy count of 150,000–400, 00 per …

Background Dozens of transplants generated from pluripotent stem cells are currently in
clinical trials. The creation of patient-specific iPSCs makes personalized therapy possible …

Glaucoma is a group of irreversible blinding eye diseases characterized by the progressive
loss of retinal ganglion cells (RGCs) and their axons. Currently, there is no effective method …

Background Although chimeric antigen receptor T (CAR-T) cells have been proven to be an
effective way of treating B cell malignancies, a lot of patients could not benefit from it …