Acidic metabolic waste products accumulate in the tumor microenvironment because of high
metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and …

Although cancer is a diverse set of diseases, cancer cells share a number of adaptive
hallmarks. Dysregulated pH is emerging as a hallmark of cancer because cancers show …

Dysregulated pH is a common characteristic of cancer cells, as they have an increased
intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells …

Cells maintain intracellular pH (pHi) within a narrow range (7.1–7.2) by controlling
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …

The pH of the tumor microenvironment drives the metastatic phenotype and
chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH …

Cell adhesion to the extracellular matrix (ECM), mediated by transmembrane receptors of
the integrin family, is exquisitely sensitive to biochemical, structural, and mechanical …

Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of
Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

The mitochondrial sirtuin SIRT3 regulates metabolic homeostasis during fasting and calorie
restriction. We identified mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 …