Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …

Cancers are the leading cause of death, causing around 10 million deaths annually by
2020. The most common cancers are those affecting the breast, lungs, colon, and rectum …

The third-generation EGFR-TKI osimertinib is widely used in EGFR-mutated positive non-
small cell lung cancer (NSCLC) patients, but drug resistance is inevitable. The currently …

Cervical cancer has become the most frequent female malignancy and presents as a
general health challenge in many countries undergoing economic development. Various …

Background Social exposures may drive epigenetic alterations that affect racial disparities in
breast cancer outcomes. This study examined the association between neighborhood-level …

The interaction of non-kinase transmembrane glycoprotein CD44 with ligands including
hyaluronic acid (HA) is closely related to the occurrence and development of tumors …

Osteosarcoma accounts for a frequently occurring cancer of the primary skeletal system. In
osteosarcoma cells, a hypoxic microenvironment is commonly observed that drives tumor …

Influenza A viruses (IAVs) initiate infection by attaching Hemagglutinin (HA) on the viral
envelope to sialic acid (SA) receptors on the cell surface. Importantly, HA of human IAVs has …

Background. Cervical cancer (CC) is a major malignancy affecting women worldwide, with
limited treatment options for patients with advanced disease. The aim of this study was to …

Sialic acid, the terminal structure of cell surface glycans, has essential functions in regulating
immune response, cell-to-cell communication, and cell adhesion. More importantly, an …