Abdominal aortic aneurysm: roles of inflammatory cells

Z Yuan, Y Lu, J Wei, J Wu, J Yang, Z Cai - Frontiers in immunology, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas.
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …

Macrophage polarization states in atherosclerosis

J Wu, S He, Z Song, S Chen, X Lin, H Sun… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis, a chronic inflammatory condition primarily affecting large and medium
arteries, is the main cause of cardiovascular diseases. Macrophages are key mediators of …

Type 2–polarized memory B cells hold allergen-specific IgE memory

JFE Koenig, NPH Knudsen, A Phelps… - Science Translational …, 2024 - science.org
Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases such as
allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by …

Long‐Chain Acyl Carnitines Aggravate Polystyrene Nanoplastics‐Induced Atherosclerosis by Upregulating MARCO

B Wang, B Liang, Y Huang, Z Li, B Zhang… - Advanced …, 2023 - Wiley Online Library
Exposure to micro‐and nanoplastics (MNPs) is common because of their omnipresence in
environment. Recent studies have revealed that MNPs may cause atherosclerosis, but the …

Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade

ML Dixon, L Luo, S Ghosh, JM Grimes… - Molecular cancer, 2021 - Springer
Abstract Background Accumulation of Foxp3+ regulatory T (Treg) cells in the tumor often
represents an important mechanism for cancer immune evasion and a critical barrier to anti …

Innate and adaptive immunity: the understudied driving force of heart valve disease

F Bartoli-Leonard, J Zimmer… - Cardiovascular research, 2021 - academic.oup.com
Calcific aortic valve disease (CAVD), and its clinical manifestation that is calcific aortic valve
stenosis, is the leading cause for valve disease within the developed world, with no current …

Humoral immunity in atherosclerosis and myocardial infarction: from B cells to antibodies

F Porsch, Z Mallat, CJ Binder - Cardiovascular research, 2021 - academic.oup.com
Immune mechanisms are critically involved in the pathogenesis of atherosclerosis and its
clinical manifestations. Associations of specific antibody levels and defined B-cell subsets …

Recent Progress in in vitro Models for Atherosclerosis Studies

J Chen, X Zhang, R Millican, T Lynd… - Frontiers in …, 2022 - frontiersin.org
Atherosclerosis is the primary cause of hardening and narrowing arteries, leading to
cardiovascular disease accounting for the high mortality in the United States. For developing …

The why and how of adaptive immune responses in ischemic cardiovascular disease

Z Mallat, CJ Binder - Nature cardiovascular research, 2022 - nature.com
Atherosclerotic cardiovascular disease is a major cause of disability and death worldwide.
Most therapeutic approaches target traditional risk factors but ignore the fundamental role of …

The impact of type 2 immunity and allergic diseases in atherosclerosis

N Fernández‐Gallego, R Castillo‐González… - Allergy, 2022 - Wiley Online Library
Allergic diseases are allergen‐induced immunological disorders characterized by the
development of type 2 immunity and IgE responses. The prevalence of allergic diseases has …