Glioblastomas are heterogeneous and invariably lethal tumours. They are characterized by
genetic and epigenetic variations among tumour cells, which makes the development of …

Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers
with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs …

Abstract Background Circular RNAs (circRNAs) have been found to play critical roles in the
development and progression of various cancers. However, little is known about the effects …

Glioblastoma (GBM) is one of the most malignant cancers of central nervous system and due
to its sensitive location, surgical resection has high risk and therefore, chemotherapy and …

Glioblastoma (GBM) is among the most deadly neoplasms associated with one of the worst
5-year overall survival (OS) rates among all human cancers. The aim of this systematic …

The niche concept was originally developed to describe the location of normal neural stem
cells (NSCs) in the subependymal layer of the sub-ventricular zone. In this paper, its …

Background Primary and adaptive resistance against chemo-and radiotherapy and local
recurrence after surgery limit the benefits from these standard treatments in glioma patients …

Surgical procedures such as tumor resection and biopsy are still the gold standard for
diagnosis and (determination of) treatment of solid tumors, and are prognostically beneficial …

Glioblastoma (GBM) is an aggressive primary tumor, causing thousands of deaths
worldwide every year. The mean survival of patients with GBM remains below 20 months …

Glioblastoma (GBM) is a particularly aggressive brain cancer associated with high
recurrence and poor prognosis. The standard of care, surgical resection followed by …