Deep-lipidotyping by mass spectrometry: recent technical advances and applications
In-depth structural characterization of lipids is an essential component of lipidomics. There
has been a rapid expansion of mass spectrometry methods that are capable of resolving …
has been a rapid expansion of mass spectrometry methods that are capable of resolving …
Enabling high structural specificity to lipidomics by coupling photochemical derivatization with tandem mass spectrometry
Conspectus Lipids have pivotal roles in many biological processes, including energy
storage, signal transduction, and plasma membrane formation. A disruption of lipid …
storage, signal transduction, and plasma membrane formation. A disruption of lipid …
Deep-profiling of phospholipidome via rapid orthogonal separations and isomer-resolved mass spectrometry
A lipidome comprises thousands of lipid species, many of which are isomers and isobars.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …
Current state of supercritical fluid chromatography-mass spectrometry
T Gazárková, K Plachká, F Svec, L Nováková - TrAC Trends in Analytical …, 2022 - Elsevier
Similarly to other hyphenated techniques, supercritical fluid chromatography (SFC) highly
benefits from the coupling with mass spectrometry (MS) detection as evident from the …
benefits from the coupling with mass spectrometry (MS) detection as evident from the …
Voltage-controlled divergent cascade of electrochemical reactions for characterization of lipids at multiple isomer levels using mass spectrometry
Cascading divergent reactions in a single system is highly desirable for their intrinsic
efficiency and potential to achieve multilevel structural characterization of complex …
efficiency and potential to achieve multilevel structural characterization of complex …
Ultrahigh-performance supercritical fluid chromatography/mass spectrometry in the lipidomic analysis
D Wolrab, O Peterka, M Chocholoušková… - TrAC Trends in …, 2022 - Elsevier
Ultrahigh-performance supercritical fluid chromatography/mass spectrometry (UHPSFC/MS)
is one of the fastest analytical approaches for high-throughput lipidomic analysis covering a …
is one of the fastest analytical approaches for high-throughput lipidomic analysis covering a …
Visible-Light Paternò–Büchi Reaction for Lipidomic Profiling at Detailed Structure Levels
The Paternò–Büchi (PB) derivatization of carbon–carbon double bond (C═ C) has been
increasingly employed with tandem mass spectrometry to analyze unsaturated lipids. It …
increasingly employed with tandem mass spectrometry to analyze unsaturated lipids. It …
A Cleavable Self-Inclusion Conjugate with Enhanced Biocompatibility and Antitumor Bioactivity
The effective encapsulation of antitumor drugs by dynamic host–guest interactions at the
submicromolar level remains a challenge. Herein, we report a cleavable self-inclusion …
submicromolar level remains a challenge. Herein, we report a cleavable self-inclusion …
Chloramine-T-enabled mass spectrometric analysis of C═ C isomers of unsaturated fatty acids and phosphatidylcholines in human thyroids
B Zhang, Y Wang, BW Zhou, J Cheng, Q Xu… - Analytical …, 2022 - ACS Publications
Specific locations of carbon–carbon double bonds (C═ C) in lipids often play an essential
role in biological processes, and there has been a booming development in C═ C …
role in biological processes, and there has been a booming development in C═ C …
Integrating the potential of ion mobility spectrometry-mass spectrometry in the separation and structural characterisation of lipid isomers
SM Camunas-Alberca, M Moran-Garrido… - Frontiers in Molecular …, 2023 - frontiersin.org
It is increasingly evident that a more detailed molecular structure analysis of isomeric lipids
is critical to better understand their roles in biological processes. The occurrence of isomeric …
is critical to better understand their roles in biological processes. The occurrence of isomeric …