Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

Wobble uridines (U34) are generally modified in all species. U34 modifications can be
essential in metazoans but are not required for viability in fungi. In this review, we provide an …

Cancer genomics has revealed many genes and core molecular processes that contribute to
human malignancies, but the genetic and molecular bases of many rare cancers remains …

Fungal pathogens threaten ecosystems and human health. Understanding the molecular
basis of their virulence is key to develop new treatment strategies. Here, we characterize …

Transfer RNA (tRNA) molecules are essential to decode messenger RNA codons during
protein synthesis. All known tRNAs are heavily modified at multiple positions through post …

Asymmetric cell division gives rise to two daughter cells that inherit different determinants,
thereby acquiring different fates. Polarized trafficking of endosomes containing fate …

The highly conserved eukaryotic Elongator complex performs specific chemical
modifications on wobble base uridines of tRNA s, which are essential for proteome stability …

The Elongator complex catalyzes posttranscriptional tRNA modifications by attaching
carboxy-methyl (cm5) moieties to uridine bases located in the wobble position. The catalytic …

Highlights•tRNA modifications strongly influence protein synthesis.•tRNAs carry several
modified bases at a time.•Target recognition and modification reactions are highly …

Transfer RNA (tRNA) is subject to a multitude of posttranscriptional modifications which can
profoundly impact its functionality as the essential adaptor molecule in messenger RNA …