The idea of using a simpler surrogate to represent a complex phenomenon has gained
increasing popularity over past three decades. Due to their ability to exploit the black-box …

The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …

The ability to accurately model and simulate chemical processes has been paramount to the
growing success and efficiency in process design and operation. These improvements …

Synthetic ammonia is essential for agriculture, but its production at present is unsustainable.
Ammonia synthesized with hydrogen from renewable-powered electrolysis and nitrogen …

It is well-documented how artificial intelligence can have (and already is having) a big
impact on chemical engineering. But classical machine learning approaches may be weak …

Energy is a key driver of the modern economy, therefore modeling and simulation of energy
systems has received significant research attention. We review the major developments in …

Optimization under uncertainty has been an active area of research for many years.
However, its application in Process Systems Engineering has faced a number of important …

Highlights•State-of-the-art review of sustainable design and synthesis of energy
systems.•Research challenges of the superstructure optimization approach.•Incorporating …

Continuous manufacturing has attracted increasing research attention in the pharmaceutical
industry within the last decade. Based on the extensive experimental studies, numerous …