Cancer-related fatigue: causes and current treatment options

MSY Thong, CJF Van Noorden, K Steindorf… - Current treatment options …, 2020 - Springer
Opinion statement Cancer-related fatigue (CRF) is a problem for a significant proportion of
cancer survivors during and after active cancer treatment. However, CRF is underdiagnosed …

Burden of anemia in chronic kidney disease: beyond erythropoietin

RM Hanna, E Streja, K Kalantar-Zadeh - Advances in therapy, 2021 - Springer
Anemia is a frequent comorbidity of chronic kidney disease (CKD) and is associated with a
considerable burden because of decreased patient health-related quality of life and …

The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation

O Marques, G Weiss… - Blood, The Journal of the …, 2022 - ashpublications.org
Anemia of inflammation (AI) is a highly prevalent comorbidity in patients affected by chronic
inflammatory disorders, such as chronic kidney disease, inflammatory bowel disease, or …

Physiology and inflammation driven pathophysiology of iron homeostasis—mechanistic insights into anemia of inflammation and its treatment

L Lanser, D Fuchs, K Kurz, G Weiss - Nutrients, 2021 - mdpi.com
Anemia is very common in patients with inflammatory disorders. Its prevalence is associated
with severity of the underlying disease, and it negatively affects quality of life and cardio …

Myelopreservation with trilaciclib in patients receiving topotecan for small cell lung cancer: results from a randomized, double-blind, placebo-controlled phase II study

LL Hart, R Ferrarotto, ZG Andric, JT Beck… - Advances in …, 2021 - Springer
Introduction Multilineage myelosuppression is an acute toxicity of cytotoxic chemotherapy,
resulting in serious complications and dose modifications. Current therapies are lineage …

Erythropoietin and its derivatives: from tissue protection to immune regulation

B Peng, G Kong, C Yang, Y Ming - Cell death & disease, 2020 - nature.com
Erythropoietin (EPO) is an evolutionarily conserved hormone well documented for its
erythropoietic role via binding the homodimeric EPO receptor (EPOR) 2. In past decades …

[PDF][PDF] Hypoxia signaling in cancer: from basics to clinical practice

A Sebestyén, L Kopper, T Dankó… - Pathology and Oncology …, 2021 - por-journal.com
Cancer hypoxia, recognized as one of the most important hallmarks of cancer, affects gene
expression, metabolism and ultimately tumor biology-related processes. Major causes of …

Perioperative anemia: prevention, diagnosis, and management throughout the spectrum of perioperative care

MA Warner, L Shore-Lesserson, A Shander… - Anesthesia & …, 2020 - journals.lww.com
Anemia is common in the perioperative period and is associated with poor patient outcomes.
Remarkably, anemia is frequently ignored until hemoglobin levels drop low enough to …

Managing anemia across the stages of kidney disease in those hyporesponsive to erythropoiesis-stimulating agents

MR Weir - American Journal of Nephrology, 2021 - karger.com
Background: Patients with CKD frequently have anemia that results from iron-restricted
erythropoiesis and inflammation. Anemia of CKD is currently managed with iron …

HIF-α prolyl hydroxylase inhibitors and their implications for biomedicine: a comprehensive review

K Hirota - Biomedicines, 2021 - mdpi.com
Oxygen is essential for the maintenance of the body. Living organisms have evolved
systems to secure an oxygen environment to be proper. Hypoxia-inducible factor (HIF) plays …