In the past, the treatment of autosomal dominant polycystic kidney disease (ADPKD) has
been limited to the management of its symptoms and complications. Recently, the US Food …

Autosomal dominant polycystic kidney disease is the most common monogenic cause of
ESKD. Genetic studies from patients and animal models have informed disease …

Background Mutations in PKD1 or PKD2 cause typical autosomal dominant polycystic
kidney disease (ADPKD), the most common monogenic kidney disease. Dominantly …

Autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic
cause of ESKD, is characterized by relentless development of kidney cysts, hypertension …

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …

Results Ninety-four intracranial aneurysms were diagnosed in 75 of 812 (9%) patients who
underwent magnetic resonance angiography screening. Sex, age, race, and genotype were …

Autosomal dominant polycystic kidney disease is a common cause of end stage kidney
disease. It is a progressive and unfortunately incurable condition that can lead to significant …

Results The age-and sex-adjusted annual incidence of definite and likely ADPKD diagnosis
during 1980–2016 was 3.06 (95% CI, 2.52 to 3.60) per 100,000 person-years, which is 2.2 …

Results Of 48 subjects randomized, 41 completed total liver volume measurements (n= 29
pasireotide long-acting release and n= 12 placebo). From baseline, there were− 99±189 …

Results Among 174 study patients with typical imaging patterns and protein-truncating PKD1
mutations, 32 (18%) were found to have mild disease on the basis of imaging results (ie …