Recognition and processing of ubiquitin-protein conjugates by the proteasome
D Finley - Annual review of biochemistry, 2009 - annualreviews.org
The proteasome is an intricate molecular machine, which serves to degrade proteins
following their conjugation to ubiquitin. Substrates dock onto the proteasome at its 19 …
following their conjugation to ubiquitin. Substrates dock onto the proteasome at its 19 …
AAA+ proteases: ATP-fueled machines of protein destruction
RT Sauer, TA Baker - Annual review of biochemistry, 2011 - annualreviews.org
AAA+ family proteolytic machines (ClpXP, ClpAP, ClpCP, HslUV, Lon, FtsH, PAN/20S, and
the 26S proteasome) perform protein quality control and are used in regulatory circuits in all …
the 26S proteasome) perform protein quality control and are used in regulatory circuits in all …
Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing
C Puchades, AJ Rampello, M Shin, CJ Giuliano… - Science, 2017 - science.org
INTRODUCTION Protein quality control is essential for mitochondrial function, and
imbalances in this regulation are associated with numerous human diseases. YME1L is a …
imbalances in this regulation are associated with numerous human diseases. YME1L is a …
Evolutionary relationships and structural mechanisms of AAA+ proteins
JP Erzberger, JM Berger - Annu. Rev. Biophys. Biomol. Struct., 2006 - annualreviews.org
Complex cellular events commonly depend on the activity of molecular “machines” that
efficiently couple enzymatic and regulatory functions within a multiprotein assembly. An …
efficiently couple enzymatic and regulatory functions within a multiprotein assembly. An …
Mechanisms of Sec61/SecY-mediated protein translocation across membranes
E Park, TA Rapoport - Annual review of biophysics, 2012 - annualreviews.org
The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
Regulated protein turnover: snapshots of the proteasome in action
The ubiquitin proteasome system (UPS) is the main ATP-dependent protein degradation
pathway in the cytosol and nucleus of eukaryotic cells. At its centre is the 26S proteasome …
pathway in the cytosol and nucleus of eukaryotic cells. At its centre is the 26S proteasome …
[HTML][HTML] Gates of enzymes
Enzymes are very efficient catalysts that are essential for the functioning of living organisms.
The low efficiency of biocatalysts produced de novo relative to those that have evolved …
The low efficiency of biocatalysts produced de novo relative to those that have evolved …
Targeting proteins for degradation
EK Schrader, KG Harstad, A Matouschek - Nature chemical biology, 2009 - nature.com
Protein degradation plays a central role in many cellular functions. Misfolded and damaged
proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins …
proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins …
Proteasome activators
BM Stadtmueller, CP Hill - Molecular cell, 2011 - cell.com
Proteasomes degrade a multitude of protein substrates in the cytosol and nucleus, and
thereby are essential for many aspects of cellular function. Because the proteolytic sites are …
thereby are essential for many aspects of cellular function. Because the proteolytic sites are …
Stairway to translocation: AAA+ motor structures reveal the mechanisms of ATP‐dependent substrate translocation
Translocases of the AAA+ (ATPases Associated with various cellular Activities) family are
powerful molecular machines that use the mechano‐chemical coupling of ATP hydrolysis …
powerful molecular machines that use the mechano‐chemical coupling of ATP hydrolysis …